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Curcumin has also been shown to improve colitis by preventing STAT3 activation and STAT3-dependent induction of cell proliferation in mouse colon.
Moreover, curcumin was shown to attenuate the immune response triggered by collagen injections in a mouse model of rheumatoid arthritis, partly by blocking the proliferation of T lymphocytes in mouse splenocytes.
Like most of these pharmacologically-active metabolites, Curcumin is involved in self-defense.
Over time, plants with higher levels of organic compounds that deter attackers become more successful, because of their advanced protection.
Inflammation is thought to be one of the major factors in all kinds of diseases, and turmeric contains loads of curcumin, a powerful anti-inflammatory substance.
Many cultures create their own botanical pharmacies as the lore of medicinal plants and remedies is handed down through generations of healers.
Whether we are healing from an injury or an autoimmune disease, inflammation is a common health challenge.
Nutritionists, functional medicine GPs and physiotherapists commonly use curcumin for its anti-inflammatory qualities.
One study compared the effectiveness of Curcumin the active ingredient in turmeric and a popular non-steroidal anti-inflammatory drug (NSAID) called phenylbutazone.
At the end of the six days, those taking the Curcumin and the NSAID enjoyed a significantly better anti-inflammatory response than placebo. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.